Trudeau F, Bernier S, de Glisezinski I, Crampes F, Dulac F, Rivière D
Département des Sciences de l'Activité Physique, Université du Québec à Trois-Rivières, Trois-Rivières, Québec, Canada G9A 5H7.
J Appl Physiol (1985). 1999 Jun;86(6):1800-4. doi: 10.1152/jappl.1999.86.6.1800.
The purpose of our study was to evaluate the potential inhibition of adipose tissue mobilization by lactate. Eight male subjects (age, 26. 25 +/- 1.75 yr) in good physical condition (maximal oxygen uptake, 59.87 +/- 2.77 ml. kg-1. min-1; %body fat, 10.15 +/- 0.89%) participated in this study. For each subject, two microdialysis probes were inserted into abdominal subcutaneous tissue. Lactate (16 mM) was perfused via one of the probes while physiological saline only was perfused via the other, both at a flow rate of 2.5 microl/min. In both probes, ethanol was also perfused for adipose tissue blood flow estimation. Dialysates were collected every 10 min during rest (30 min), exercise at 50% maximal oxygen consumption (120 min), and recovery (30 min) for the measurement of glycerol concentration. During exercise, glycerol increased significantly in both probes. However, no differences in glycerol level and ethanol extraction were observed between the lactate and control probes. These findings suggest that lactate does not impair subcutaneous abdominal adipose tissue mobilization during exercise.
我们研究的目的是评估乳酸对脂肪组织动员的潜在抑制作用。八名身体状况良好的男性受试者（年龄26.25±1.75岁）参与了本研究（最大摄氧量59.87±2.77 ml·kg⁻¹·min⁻¹；体脂率10.15±0.89%）。对于每位受试者，将两根微透析探针插入腹部皮下组织。通过其中一根探针灌注乳酸（16 mM），而另一根仅灌注生理盐水，流速均为2.5微升/分钟。在两根探针中，还灌注乙醇以估计脂肪组织血流量。在静息状态（30分钟）、50%最大摄氧量运动（120分钟）和恢复阶段（30分钟）期间，每10分钟收集一次透析液，用于测量甘油浓度。运动期间，两根探针中的甘油均显著增加。然而，乳酸探针和对照探针之间在甘油水平和乙醇提取方面未观察到差异。这些发现表明，乳酸在运动期间不会损害腹部皮下脂肪组织的动员。
