氯苯那敏对映体与人血浆蛋白的结合

Binding of chlorpheniramine enantiomers to human plasma proteins.

作者信息

Hiep B T, Gimenez F, Khanh V U, Hung N K, Thuillier A, Farinotti R, Fernandez C

机构信息

Pitié Salpêtrière Hospital Pharmacy, Paris, France.

出版信息

Chirality. 1999;11(5-6):501-4. doi: 10.1002/(SICI)1520-636X(1999)11:5/6<501::AID-CHIR24>3.0.CO;2-K.

DOI:10.1002/(SICI)1520-636X(1999)11:5/6<501::AID-CHIR24>3.0.CO;2-K

PMID:10368923

Abstract

The in vitro binding of RS-chlorpheniramine to human proteins was studied by equilibrium dialysis. The binding to total plasma proteins and to individual albumin and alpha-glycoprotein acid is stereoselective. (+)S-chlorpheniramine is more extensively bound than its antipode to total plasma proteins (38% vs. 23%), to albumin (20% vs. 15%) and to alpha-glycoprotein acid (23% vs. 5%).

摘要

通过平衡透析研究了消旋氯苯那敏与人蛋白质的体外结合。其与总血浆蛋白以及单个白蛋白和α-酸性糖蛋白的结合具有立体选择性。（+）S-氯苯那敏比其对映体与总血浆蛋白（38%对23%）、白蛋白（20%对15%）和α-酸性糖蛋白（23%对5%）的结合更广泛。