Fernandez C, Gimenez F, Thuillier A, Farinotti R
Hôpital Pitié-Salpêtrière, Service Pharmacie-Pharmacocinétique, Paris, France.
Chirality. 1999;11(2):129-32. doi: 10.1002/(SICI)1520-636X(1999)11:2<129::AID-CHIR8>3.0.CO;2-E.
The binding of racemic zopiclone (ZOP) and of its two enantiomers to plasma proteins, albumin and alpha 1-acid glycoprotein were compared. Our work shows that the binding of ZOP to human plasma proteins is stereoselective. The total plasma protein binding percentages were 79.3 +/- 5.5%, 83.8 +/- 5.2%, and 75.1 +/- 2.1%, for racemic zopiclone, (-)zopiclone and (+)zopiclone, respectively. These results were confirmed by the analysis of samples obtained from healthy volunteers after the oral administration of ZOP. The anticoagulant used for sampling was also shown to have an influence on the percentage binding and on its stereoselectivity. Considering albumin and alpha 1-acid glycoprotein separately, stereoselectivity was also observed.
