Benazzi F
Eur Arch Psychiatry Clin Neurosci. 1999;249(2):62-5. doi: 10.1007/s004060050067.
The diagnostic validity of atypical depression is based on its superior response to monoamine oxidase inhibitors compared to tricyclic antidepressants, and on latent class analysis. The studies on atypical depression have often not included bipolar patients. The aim of the present study was to find the prevalence of bipolar II disorder among DSM-IV atypical depression outpatients. Bipolar II and unipolar atypical depressions were also compared to find if they were variants of the same disorder or if instead they were different disorders. One hundred and forty consecutive unipolar and bipolar II outpatients, presenting for treatment of an atypical major depressive episode, were interviewed with the Structured Clinical Interview for DSM-IV, the Montgomery Asberg Depression Rating Scale (MADRS), and the Global Assessment of Functioning Scale. The prevalence of bipolar II disorder was 64.2%. The age at baseline and onset were significantly lower in bipolar II versus unipolar patients. All the other variables (MADRS items, duration of illness, severity, gender, psychosis, comorbidity, chronicity, recurrences) were not significantly different. The prevalence of bipolar II disorder among atypical depressed outpatients was higher than previously reported.
非典型抑郁症的诊断效度基于其相对于三环类抗抑郁药对单胺氧化酶抑制剂有更好的反应，以及基于潜在类别分析。关于非典型抑郁症的研究常常未纳入双相情感障碍患者。本研究的目的是找出在《精神疾病诊断与统计手册》第四版（DSM-IV）非典型抑郁症门诊患者中双相II型障碍的患病率。还对双相II型和单相非典型抑郁症进行了比较，以确定它们是同一疾病的不同变体，还是属于不同的疾病。对连续140名单相和双相II型门诊患者进行了访谈，这些患者因非典型重度抑郁发作前来接受治疗，访谈采用了《精神疾病诊断与统计手册》第四版的结构化临床访谈、蒙哥马利-阿斯伯格抑郁评定量表（MADRS）和功能总体评定量表。双相II型障碍的患病率为64.2%。双相II型患者的基线年龄和发病年龄显著低于单相患者。所有其他变量（MADRS项目、病程、严重程度、性别、精神病性症状、共病、慢性病程、复发情况）并无显著差异。非典型抑郁症门诊患者中双相II型障碍的患病率高于先前报道。
