Wendt V H, Reckers R
Arzneimittelforschung. 1976;26(7b):1495-8.
The efficacy of a new topical corticosteroid, 6alpha,9-difluor-11beta-hylerate, Nerisona), as a 0.1% cream, ointment and fatty ointment was investigated in the vasoconstriction test in two series of studies after application to human skin in which hyperaemia had been experimentally induced. The diflucortolone valerate W/O emulsion proved to be 100 times more effective than fluocortolone in an identical base. In a further study diflucortolone valerate as well as in the three preparations was compared with nine known corticosteroids or their commercial preparations. In the comparison of the preparations only the cream with 0.05% betamethasone-17,21-dipropionate was superior to the diflucortolone valerate cream. As regards all the other preparations of formulations the new substance proved to be more or at least equally effective.
一种新型外用皮质类固醇6α,9 - 二氟 - 11β - 羟戊酸酯（Nerisona）制成0.1%乳膏、软膏和脂肪性软膏后，在两个系列研究的血管收缩试验中进行了研究，这些研究是在将其应用于实验性诱导充血的人体皮肤后开展的。戊酸倍他米松水包油乳剂在相同基质中被证明比氟轻松有效100倍。在另一项研究中，将戊酸倍他米松以及这三种制剂与九种已知皮质类固醇或其商业制剂进行了比较。在制剂比较中，只有含0.05%倍他米松 - 17,21 - 二丙酸酯的乳膏优于戊酸倍他米松乳膏。对于所有其他制剂配方，该新物质被证明更有效或至少同样有效。
