一些新型生物活性噻二唑并三嗪酮的合成——第二部分。
Synthesis of some new biologically active thiadiazolotriazinones--Part II.
作者信息
Holla B S, Sarojini B K, Shridhara K, Antony G
机构信息
Mangalore University, Department of Post Graduate Studies and Research in Chemistry, Mangalagangothri, India.
出版信息
Farmaco. 1999 Mar 31;54(3):149-51. doi: 10.1016/s0014-827x(99)00008-7.
4-Amino-6-phenyl/methyl-3-mercapto-1,2,4-triazin-5(4H)-ones (1) are condensed with an aromatic carboxylic acid, aryloxyacetic acid or anilinoacetic acid (2), to yield 7-substituted-3-phenyl/methyl-4H-1,3,4-thiadiazolo-[2,3-c]-1,2,4-+ ++triazin-4- ones (3). Phosphorus oxychloride is used as a cyclizing agent. All the synthesized compounds are screened for their antibacterial activities against S. aureus, E. coli, P. aeruginosa and G. bacillus.
4-氨基-6-苯基/甲基-3-巯基-1,2,4-三嗪-5(4H)-酮(1)与芳族羧酸、芳氧基乙酸或苯胺基乙酸(2)缩合，得到7-取代-3-苯基/甲基-4H-1,3,4-噻二唑并-[2,3-c]-1,2,4-三嗪-4-酮(3)。使用三氯氧磷作为环化剂。对所有合成化合物针对金黄色葡萄球菌、大肠杆菌、铜绿假单胞菌和芽孢杆菌的抗菌活性进行筛选。
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