Morland J, Holm T, Prydz H
Thromb Haemost. 1976 Dec 31;36(3):532-6.
The effect of chronic administration of ethanol to rats in a controlled regimen upon the activities of the coagulation factors II, VII, VIII, IX and X has been studied. No significant differences were found for factor II, IX and X between the ethanol-treated rats and the control group given an isocaloric diet with carbohydrate replacing ethanol. Factor VII activity was somewhat higher and factor VIII activity decreased significantly in the experimental group when ethanol treatment was combined with an approximately two-fold increase in dietary polyunsaturated fatty acid.
研究了在可控方案下对大鼠长期给予乙醇，对凝血因子II、VII、VIII、IX和X活性的影响。在给予乙醇的大鼠与给予用碳水化合物替代乙醇的等热量饮食的对照组之间，凝血因子II、IX和X未发现显著差异。当乙醇处理与饮食中多不饱和脂肪酸增加约两倍相结合时，实验组的凝血因子VII活性有所升高，而凝血因子VIII活性显著降低。
