白细胞介素-2对接受高效抗逆转录病毒治疗的HIV-1感染患者中潜伏感染的静息CD4+ T细胞库的影响。

Effect of interleukin-2 on the pool of latently infected, resting CD4+ T cells in HIV-1-infected patients receiving highly active anti-retroviral therapy.

作者信息

Chun T W, Engel D, Mizell S B, Hallahan C W, Fischette M, Park S, Davey R T, Dybul M, Kovacs J A, Metcalf J A, Mican J M, Berrey M M, Corey L, Lane H C, Fauci A S

机构信息

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.

出版信息

Nat Med. 1999 Jun;5(6):651-5. doi: 10.1038/9498.

DOI:10.1038/9498

PMID:10371503

Abstract

The size of the pool of resting CD4+ T cells containing replication-competent HIV in the blood of patients receiving intermittent interleukin (IL)-2 plus highly active anti-retroviral therapy (HAART) was significantly lower than that of patients receiving HAART alone. Virus could not be isolated from the peripheral blood CD4+ T cells in three patients receiving IL-2 plus HAART, despite the fact that large numbers of resting CD4+ T cells were cultured. Lymph node biopsies were done in two of these three patients and virus could not be isolated. These results indicate that the intermittent administration of IL-2 with continuous HAART may lead to a substantial reduction in the pool of resting CD4+ T cells that contain replication-competent HIV.

摘要

接受间歇性白细胞介素（IL）-2联合高效抗逆转录病毒疗法（HAART）的患者血液中，含有具有复制能力的HIV的静止CD4+ T细胞池的大小，显著低于仅接受HAART的患者。在三名接受IL-2联合HAART的患者中，尽管培养了大量静止CD4+ T细胞，但外周血CD4+ T细胞中未能分离出病毒。对这三名患者中的两名进行了淋巴结活检，也未能分离出病毒。这些结果表明，IL-2与持续HAART的间歇性给药可能会导致含有具有复制能力的HIV的静止CD4+ T细胞池大幅减少。