Papayannopoulou T
Department of Medicine, University of Washington, Seattle 98195-7710, USA.
Ann N Y Acad Sci. 1999 Apr 30;872:187-97; discussion 197-9. doi: 10.1111/j.1749-6632.1999.tb08464.x.
The physiologic egress of mature hemopoietic cells and of hemopoietic stem/progenitor cells from bone marrow to the circulation are poorly understood processes. Likewise, the mechanism of their enforced emigration or mobilization through the use of several agents has not been unraveled. Although mobilization is suspected to be a multi-step process, involving sequential and/or overlapping changes in adhesion and migratory capacity, a model of molecular hierarchy, like the one governing the extravasation of mature leukocytes to tissues of inflammation, has not been worked out. Understanding the in vivo mechanism of mobilization has been a challenge. Signals emanating from both stromal cells and from hemopoietic cells are likely involved. However, dissecting out their roles, specificity, and interactions has been difficult. Nevertheless insightful information is rapidly emerging, especially with the current availability of many mouse models bearing targeted disruptions of cytoadhesion or signaling molecules.
成熟造血细胞以及造血干/祖细胞从骨髓向循环系统的生理性流出是尚未被充分理解的过程。同样,通过使用多种药物促使它们迁移或动员的机制也尚未阐明。尽管人们怀疑动员是一个多步骤过程,涉及黏附力和迁移能力的相继和/或重叠变化,但尚未建立起像控制成熟白细胞向炎症组织渗出那样的分子层级模型。了解体内动员机制一直是一项挑战。基质细胞和造血细胞发出的信号可能都参与其中。然而,剖析它们的作用、特异性和相互作用一直很困难。尽管如此,有价值的信息正在迅速涌现,特别是鉴于目前有许多携带细胞黏附或信号分子靶向破坏的小鼠模型。