Jaiswal Siddhartha, Weissman Irving L
Ludwig Center at Stanford, Stanford Cancer Center, Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ann N Y Acad Sci. 2009 Sep;1174:118-21. doi: 10.1111/j.1749-6632.2009.04930.x.
Cells of the vertebrate immune system are continuously regenerated by division of hematopoietic stem cells (HSCs) into differentiated effector cells. Classically, HSCs were thought to reside primarily in the bone marrow niche where they produced mature progeny that migrated from the marrow to repopulate the peripheral immune system. However, emerging evidence has established that hematopoietic stem and progenitor cells (HSPCs) are themselves mobile and able to repopulate ectopic niches and contribute more directly to inflammatory responses in the periphery. How the HSPCs remain immune to destruction in a toxic inflammatory milieu is unknown.
脊椎动物免疫系统的细胞通过造血干细胞（HSC）分化为分化效应细胞而不断再生。传统上，人们认为造血干细胞主要存在于骨髓微环境中，在那里它们产生成熟的子代细胞，这些子代细胞从骨髓迁移出来以重新填充外周免疫系统。然而，新出现的证据表明，造血干细胞和祖细胞（HSPC）本身具有移动性，能够重新填充异位微环境，并更直接地参与外周的炎症反应。HSPC如何在有毒的炎症环境中免受破坏尚不清楚。
