Pálosi E, Szporny L
Arzneimittelforschung. 1976;26(10a):1926-9.
Side effects of ethyl apovincaminate (RGH-4405, Cavinton), a cerebral vasodilatory agent, on the central nervous system were studied on mice and rats. Anticonvulsive effect in electroshock was observed as major CNS effect, locomotor activity was reduced due to muscle relaxant effect. The compound had no sedative effect on rodents. Its analgesic effect was negligible. Cavinton had neither antidepressive, nor anticholinergic activity.
对脑血管扩张剂长春乙酯（RGH - 4405，卡温顿）对小鼠和大鼠中枢神经系统的副作用进行了研究。观察到其对电休克的抗惊厥作用是主要的中枢神经系统效应，由于肌肉松弛作用，运动活性降低。该化合物对啮齿动物没有镇静作用。其镇痛作用可忽略不计。卡温顿既没有抗抑郁活性，也没有抗胆碱能活性。
