Ribári O, Zelen B, Kollár B
Arzneimittelforschung. 1976;26(10a):1977-80.
Ethyl apovincaminate (EGH-4405, Cavinton) treatment has been used in various sensorineural impairments of hearing as well as in ear diseases associated with vertigo. As shown by experinces, presbyacusis, vascular impairment of hearing and in certain cases toxic hypacusia are improved by Cavinton. Besides audiometric improvement of pure tone, significant improvement was noted in the speech-audiogram in all three groups of disease. Certain affections of the ear accompanied by vertigo responded to Cavinton. In Menière's disease it has proved to be superior to the vasodilators used up to now.
长春乙酯(EGH - 4405,卡温顿)已用于各种感音神经性听力障碍以及与眩晕相关的耳部疾病。经验表明,卡温顿可改善老年性耳聋、听力血管性损害以及某些情况下的中毒性听力减退。除了纯音听力测定有所改善外,在所有三组疾病的言语听力图中也有显著改善。某些伴有眩晕的耳部疾病对卡温顿有反应。在梅尼埃病中,它已被证明优于目前使用的血管扩张剂。