Aliprandi G, Tantalo V
Arzneimittelforschung. 1979;29(8a):1287-95.
Many experimental investigations have shown that labyrinthine fluids play a basic role in the physiology of the inner ear. Modifications of perilymphatic fluids have been demonstrated in perceptive deafness (otosclerosis, Ménière's disease, tympanolabyrinthosclerosis). Vasoactive agents fail to markedly affect the exchange between labyrinthine fluids, so that perceptive syndromes are generally regarded as unresponsive to treatment. Several studies have shown the effectiveness of 10-methoxy-1,6-diemthyl-ergoline-8 beta-methanol-(5-bromonicotinate) (nicergoline, Sermion) in various conditions of the inner ear. In this investigation, 30 patients with presbyacusis were treated with 30 mg/day p.o. for 30 days. Speech audiometric curves were improved in 4 out of 18 cases of physiological presbyacusis and in 6 out of 12 cases of accelerated presbyacusis. These results are very interesting, since few effective therapies are available to treat these conditions.
许多实验研究表明，内耳液在内耳生理学中起着基础性作用。在感音性聋（耳硬化症、梅尼埃病、鼓室迷路硬化症）中已证实外淋巴液有改变。血管活性药物未能显著影响内耳液之间的交换，因此感音综合征通常被认为对治疗无反应。多项研究表明10-甲氧基-1,6-二甲基麦角灵-8β-甲醇-（5-溴烟酸酯）（尼麦角林，喜得镇）在各种内耳疾病中有效。在本研究中，30例老年聋患者口服给药，每天30mg，持续30天。在18例生理性老年聋患者中有4例以及12例加速性老年聋患者中有6例言语听力计曲线得到改善。这些结果非常有趣，因为治疗这些疾病的有效疗法很少。
