[HARP在血管生成中的意义及可能的治疗作用]

[Implication of HARP in angiogenesis and possible therapeutic role].

作者信息

Delbe J, Katsoris P, Milhiet P E, Barritault D, Caruelle D, Courty J

机构信息

Laboratoire de Recherche sur la Croissance Cellulaire, la Réparation et la Régénération Tissulaires (CRRET), UPRESA CNRS 7053, Université Paris Val-de-Marne, Creteil, France.

出版信息

Pathol Biol (Paris). 1999 Apr;47(4):352-7.

PMID:10372404

Abstract

HARP (heparin affin regulatory peptide), also called pleiotrophin (PTN), belongs to the heparin binding growth factors (HBGFs) family. Several new data suggest a role for HARP during the various stages of angiogenesis. In vivo, HARP is localised in endothelial cells of blood capillaries. In vitro, HARP displays mitogenic activity on endothelial cells, induces the formation of capillary-like structures in collagen gel, and degrades extracellular matrix via stimulation of plasminogen activator activity. HARP is also involved in neoangiogenesis during tumor progression. This review discusses the possible role of HARP in tumor angiogenesis and its therapeutic implications.

摘要

肝素亲和调节肽（HARP），也称为多效生长因子（PTN），属于肝素结合生长因子（HBGFs）家族。一些新数据表明HARP在血管生成的各个阶段发挥作用。在体内，HARP定位于毛细血管的内皮细胞中。在体外，HARP对内皮细胞具有促有丝分裂活性，可诱导胶原凝胶中形成毛细血管样结构，并通过刺激纤溶酶原激活物活性来降解细胞外基质。HARP还参与肿瘤进展过程中的新生血管生成。本文综述讨论了HARP在肿瘤血管生成中的可能作用及其治疗意义。