Ganz H, Knappen F
Arzneimittelforschung. 1976;26(11):2061-5.
We examined the degree of dependency of the ECG parameters PO, QRS and QT on the heart rate. In 252 beagles of standardised breeding and accommodation (strain: Chbi : BEAGLE), a total of 1456 ECG recordings was made from the three Einthoven extremity leads, and the heart rate and PQ-, QRS-, and QT-times were measured. The animals used were dogs from eleven subacute toxicity studies. 683 of the registrations were obtained from control animals and 773 from drug-treated animals whose ECG curves had remained unchanged and in which no histopathological changes were found in the heart at the end of the toxicity studies. The data obtained were biometrically evaluated by regression and correlation analyses. The range of the heart rate was 34-238 actions/min, median value 108. The range of the PQ interval was 0.07-0.18 sec, the QRS interval 0.03-0.09 sec and the QT interval 0.14-0.26 sec. The median values were 0.11, 0.05 and 0.19 sec, respectively. Positive skew distributions were found. The data were transformed to obtain values with normal distribution. The various correlation coefficients were then heart rate/PQ time: -0.408 (p less than 0.001), heart rate/QRS time: -0.057 (p less than 0.05), heart rate/QT time: - 0.611 (p less than 0.001). This means that the PQ and QT intervals clearly decrease as the heart rate increases, whereas the QRS interval is only minimally affected. Correlation ellipses were also calculated and presented graphically. These show areas within which 50, 75, 90 and 95% of our values are to be expected.
我们研究了心电图参数P波、QRS波和QT间期对心率的依赖程度。在252只标准化饲养和安置的比格犬（品系：Chbi : BEAGLE）中，从三个肢体导联共记录了1456份心电图，并测量了心率以及P波、QRS波和QT间期。所用动物来自11项亚急性毒性研究中的犬只。683份记录来自对照动物，773份来自药物治疗动物，这些动物的心电图曲线未发生变化，且在毒性研究结束时心脏未发现组织病理学改变。通过回归和相关分析对所得数据进行生物统计学评估。心率范围为34 - 238次/分钟，中位数为108次/分钟。PQ间期范围为0.07 - 0.18秒，QRS间期为0.03 - 0.09秒，QT间期为0.14 - 0.26秒。中位数分别为0.11秒、0.05秒和0.19秒。发现呈正偏态分布。对数据进行转换以获得呈正态分布的值。然后得到的各种相关系数为：心率/PQ间期：-0.408（p < 0.001），心率/QRS间期：-0.057（p < 0.05），心率/QT间期：-0.611（p < 0.001）。这意味着随着心率增加，PQ和QT间期明显缩短，而QRS间期仅受到极小影响。还计算了相关椭圆并以图形形式呈现。这些椭圆显示了预期我们50%、75%、90%和95%的值所在的区域。
