南美印第安人中的新型 HLA - A 和 HLA - B 等位基因。

Novel HLA-A and HLA-B alleles in South American Indians.

作者信息

Marcos C Y, Fernández-Viña M A, Lázaro A M, Moraes M E, Moraes J R, Stastny P

机构信息

Department of Internal Medicine, University of Texas, Southwestern Medical Center, Dallas 75235-8886, USA.

出版信息

Tissue Antigens. 1999 May;53(5):476-85. doi: 10.1034/j.1399-0039.1999.530504.x.

DOI:10.1034/j.1399-0039.1999.530504.x

PMID:10372543

Abstract

The human leukocyte antigen (HLA) complex includes the most polymorphic genes in humans. More than 600 allelic variants have been described in different populations. The HLA-B locus has contributed the largest number of alleles. Although Native American populations display a restricted number of HLA-alleles, many novel HLA class I alleles have been identified in indigenous communities of Central and South America. We have studied 248 unrelated individuals from three tribes of North-East Argentina and one from South-West Brazil, as well as 80 related individuals from the Brazilian tribe. In the course of this work, we found 8 new B-locus alleles and 2 novel A-locus alleles in these populations. Here we report the nucleotide sequences of A0219, A0222, B3519, B3520, B3521, B3912, B4009 and B4803 and we show their relationship with similar alleles. The new alleles B35092 and B3518 have been described by us in a previous paper. The possible mechanisms that may have produced these alleles over evolutionary time are discussed.

摘要

人类白细胞抗原（HLA）复合体包含人类中多态性最高的基因。在不同人群中已描述了600多种等位基因变体。HLA - B基因座贡献的等位基因数量最多。尽管美洲原住民群体中HLA等位基因数量有限，但在中美洲和南美洲的土著社区中已鉴定出许多新的HLA I类等位基因。我们研究了来自阿根廷东北部三个部落和巴西西南部一个部落的248名无亲缘关系个体，以及来自巴西部落的80名有亲缘关系个体。在这项工作过程中，我们在这些人群中发现了8个新的B基因座等位基因和2个新的A基因座等位基因。在此，我们报告A0219、A0222、B3519、B3520、B3521、B3912、B4009和B4803的核苷酸序列，并展示它们与相似等位基因的关系。新等位基因B35092和B3518已在我们之前的一篇论文中描述。本文还讨论了在进化过程中可能产生这些等位基因的潜在机制。