一例癫痫性负性肌阵挛：治疗考量

A case of epileptic negative myoclonus: therapeutic considerations.

作者信息

Shirasaka Y, Mitsuyoshi I

机构信息

Department of Pediatrics, Kansai Regional Epilepsy Center, National Utano Hospital, Kyoto, Japan.

出版信息

Brain Dev. 1999 Apr;21(3):209-12. doi: 10.1016/s0387-7604(99)00005-4.

DOI:10.1016/s0387-7604(99)00005-4

PMID:10372909

Abstract

This study presents a patient with epileptic negative myoclonus who showed interictal focal epileptic discharges in the centrotemporal region. The patient's seizures were exacerbated by carbamazepine, zonisamide, and valproate, but completely controlled by ethosuximide, and were suggested to have some relation with thalamocortical oscillation mechanisms. Ethosuximide is supposed to be a drug of worth to try to use in epileptic negative myoclonus patients with centrotemporal spike foci.

摘要

本研究报告了一名患有癫痫性负性肌阵挛的患者，其在发作间期中央颞区出现局灶性癫痫放电。卡马西平、唑尼沙胺和丙戊酸盐会加重该患者的癫痫发作，但乙琥胺可完全控制发作，提示其与丘脑皮质振荡机制存在某种关联。对于具有中央颞棘波灶的癫痫性负性肌阵挛患者，乙琥胺被认为是一种值得尝试使用的药物。