[人胶质瘤中p53、c-erbB1、c-myc和p16基因蛋白的表达]
[Expression of p53, c-erbB1, c-myc and p16 gene proteins in human glioma].
作者信息
Zhu R, Kang S, Wu D
机构信息
Department of Pathology, First Hospital Affiliated to Suzhou Medical College.
出版信息
Zhonghua Bing Li Xue Za Zhi. 1997 Dec;26(6):343-5.
OBJECTIVE
To realize the significance of c-erbB1 and c-myc protooncogenes, p53 and p16 tumor suppressor genes in the development and pathologic diagnosis of human glioma.
METHODS
The expression of p53, c-erbB1, c-myc and p16 gene proteins was detected immunohistochemically in 65 cases of glioma. The relationship between these results and the pathological grades was determined.
RESULTS
The overexpression of mutant p53, c-erbB1 and c-myc was in accordance with the increasing grade of glioma malignancy, showing significant difference (P < 0.05) between the benign group and highly malignant group in p53 and c-erbB1, while the deletion of p16 protein was more frequent in the highly malignant group than in any other group. These 4 genes showed co-expression in some of the gliomas.
CONCLUSIONS
The 4 genes, especially p53 and c-erbB1, play an important role in the development of glioma; the detection of these gene proteins has a positive significance on malignancy determination for glioma.
目的
了解c-erbB1和c-myc原癌基因、p53和p16抑癌基因在人脑胶质瘤发生发展及病理诊断中的意义。
方法
采用免疫组化方法检测65例胶质瘤中p53、c-erbB1、c-myc和p16基因蛋白的表达情况，并分析其与病理分级的关系。
结果
突变型p53、c-erbB1和c-myc的过表达与胶质瘤恶性程度的增加一致，p53和c-erbB1在良性组与高度恶性组之间差异有统计学意义（P<0.05）；p16蛋白缺失在高度恶性组中比其他组更常见。这4种基因在部分胶质瘤中存在共表达。
结论
这4种基因，尤其是p53和c-erbB1，在胶质瘤的发生发展中起重要作用；检测这些基因蛋白对胶质瘤的恶性程度判定有积极意义。
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