Xiao J, Zhao D, Hou T, Wu K, Zeng H
Department of Orthopaedics, Changzheng Hospital, Second Military Medical College University, Shanghai, China.
Chin Med J (Engl). 1998 May;111(5):443-6.
To investigate the effects of combined blockade by platelet activating factor (PAF) receptor antagonist BN52021 in combination with opiate receptor antagonist naloxone on neurological function and neurological tissue damage after cervical cord injury.
Spinal cord contusion at C6 segment was made with Allen method in cats, which were randomly divided into four groups: saline control group; BN52021 group; naloxone group; and combined treatment group with BN52021 and naloxone. Alteration of cervical cord blood flow, blood barrier permeability of the spinal cord, cervical cord tissue pathology and neurological functional scores were studied after experimental cervical cord injury.
The animals treated with BN52021 or naloxone had significantly better functional scores than saline controls 6 weeks after injury (P < 0.05). Moreover, the combined treatment showed significantly better neurologic recovery than either naloxone or BN52021 treated animals (P < 0.05). The other indexes in combined treatment animals were also superior to those in naloxone or BN52021 treated animals.
Combined blockade by two kinds of autolesion mediator receptor can more effectively inhibit secondary damage production and development after cervical cord injury and improve neurologic function.
探讨血小板活化因子（PAF）受体拮抗剂BN52021与阿片受体拮抗剂纳洛酮联合阻断对颈髓损伤后神经功能及神经组织损伤的影响。
采用Allen法对猫进行C6节段脊髓挫伤，将其随机分为四组：生理盐水对照组；BN52021组；纳洛酮组；BN52021与纳洛酮联合治疗组。观察实验性颈髓损伤后颈髓血流变化、脊髓血脑屏障通透性、颈髓组织病理学及神经功能评分。
损伤6周后，BN52021或纳洛酮治疗的动物功能评分明显优于生理盐水对照组（P < 0.05）。此外，联合治疗组的神经功能恢复明显优于纳洛酮或BN52021治疗组（P < 0.05）。联合治疗组的其他指标也优于纳洛酮或BN52021治疗组。
两种自身损伤介质受体联合阻断能更有效地抑制颈髓损伤后的继发性损伤发生和发展，改善神经功能。
