Zhou J, Wu D, Zhu Y
Institute for Cardio- & Cerebro-vascular Diseases, Second Hospital, Zhejiang Medical University, Hangzhou.
Zhonghua Yu Fang Yi Xue Za Zhi. 1998 Nov;32(6):333-5.
To explore the relationship between nitric oxide, oxidation, lipoperoxidation and silicosis.
Blood plasma levels of nitric oxide (P-NO), vitamin C (P-VC), vitamin E (P-VE), beta-carotene (P-beta-CAR), lipoperoxidase (P-LPO), and erythrocyte activities of superoxide dismutase (E-SOD), catalase (E-CAT), glutathione peroxidase (E-GSH-Px) and lipoperoxidase (E-LPO) were measured in 73 patients with silicosis and 60 healthy subjects.
The average levels of P-VC, P-VE, P-beta-CAR, E-SOD, E-CAT and E-GSH-Px were significantly lower and the average levels of P-NO, P-LPO and E-LPO significantly increased in the silicosis with varied severity of the disease and lung function status more than in the controls. There was linear relationship between all the above indices and length of the disease. Stepwise regression analysis showed that the severity of the disease and lung function status correlated most closely with the levels of P-NO, P-VE, E-SOD and E-LPO.
Metabolism of nitric oxide was abnormal, balance between oxidation and antioxidation was disturbed seriously, and oxidation and lipoperoxidation reaction pathologically exacerbated in the bodies of the patient with silicosis.
探讨一氧化氮、氧化、脂质过氧化与矽肺之间的关系。
检测73例矽肺患者和60名健康对照者血浆中一氧化氮（P-NO）、维生素C（P-VC）、维生素E（P-VE）、β-胡萝卜素（P-β-CAR）、脂质过氧化物酶（P-LPO）水平，以及红细胞中超氧化物歧化酶（E-SOD）、过氧化氢酶（E-CAT）、谷胱甘肽过氧化物酶（E-GSH-Px）和脂质过氧化物酶（E-LPO）活性。
不同病情严重程度及肺功能状态的矽肺患者，其P-VC、P-VE、P-β-CAR、E-SOD、E-CAT和E-GSH-Px平均水平显著低于对照组，而P-NO、P-LPO和E-LPO平均水平显著高于对照组。上述所有指标与病程均呈线性关系。逐步回归分析显示，病情严重程度及肺功能状态与P-NO、P-VE、E-SOD和E-LPO水平相关性最为密切。
矽肺患者体内一氧化氮代谢异常，氧化与抗氧化平衡严重失调，氧化及脂质过氧化反应呈病理性加剧。
Zotero 插件