Frati R, Frati C, Sassano P P, Antonaci A
Dept. of Maxillofacial Surgery, University La Sapienza, Rome, Italy.
J Exp Clin Cancer Res. 1999 Mar;18(1):85-7.
An association between vitiligo and autoimmune thyroid disorders had previously been postulated. Thyroid disorders were found in 18.5% of 15,126 patients with vitiligo, on the basis of the anamnestic data. Then, we investigated 255 healthy relatives in whom we tested only T3, T4 and TSH. With the immunological investigation we detected a higher incidence of TMA in vitiligo patients and in the family members. Therefore, on the basis of the immunologic and thyroid pathology functional data, we observed a thyroid pathology in 25% of the 890 vitiligo patients and in 21.1% of their first degree relatives. Then, clinical observation enabled to discover that 3 of 15,126 patients had undergone exeresis for a thyroid carcinoma and in the 890 vitiligo patients, who had undergone particular investigations, we found a thyroid carcinoma in 3 subjects. In one case lymphnodal involvement and bone metastases in the maxillary district were found. The purpose of this work is to evaluate the incidence of thyrosis and of thyroid carcinoma in vitiligo patients observed for 20 years.
白癜风与自身免疫性甲状腺疾病之间的关联此前已有推测。根据既往病史资料，在15126例白癜风患者中，发现18.5%患有甲状腺疾病。随后，我们对255名健康亲属进行了调查，仅检测了他们的T3、T4和TSH。通过免疫学调查，我们在白癜风患者及其家庭成员中检测到较高的甲状腺微粒体抗体（TMA）发生率。因此，根据免疫学和甲状腺病理学功能数据，我们在890例白癜风患者中观察到25%存在甲状腺病变，在其一级亲属中这一比例为21.1%。随后，临床观察发现，1512例患者中有3例因甲状腺癌接受了手术切除，在接受了特殊检查的890例白癜风患者中，我们发现有3例患有甲状腺癌。其中1例发现有淋巴结受累及上颌区骨转移。本研究的目的是评估对白癜风患者进行20年观察后甲状腺疾病和甲状腺癌的发病率。
