Gormley P D, Pavesio C E, Luthert P, Lightman S
Institute of Ophthalmology and Moorfields Eye Hospital, City Road, London, EC1V 2PD, UK.
Exp Eye Res. 1999 Jun;68(6):657-61. doi: 10.1006/exer.1998.0655.
Administration of Toxoplasma cysts by intraperitoneal innoculation in the Syrian Golden Hamster provides a reproducible animal model of acquired Toxoplasmic retinochoroiditis and cysts are observed in the brain. However, toxoplasmosis is frequently acquired by oral ingestion of contaminated foodstuffs and it is recognised that the route by which disease is acquired may influence its pathogenesis and clinical expression. This study aimed to determine whether retinochorioiditis and cysts in the brain develop after oral ingestion in the Syrian Golden Hamster model as this is the route of induction akin to that in man and may therefore be more relevant in the study of disease pathogenesis. All animals developed disease by 4 weeks. Ocular and cerebral inflammation was confirmed by histology at 16 weeks and this was milder than in the original model.
通过腹腔接种将弓形虫囊肿接种到叙利亚金仓鼠体内，可提供一种可重复的获得性弓形虫视网膜脉络膜炎动物模型，并且在大脑中可观察到囊肿。然而，弓形虫病常常是通过口服受污染的食物而感染的，而且人们认识到感染疾病的途径可能会影响其发病机制和临床表现。本研究旨在确定在叙利亚金仓鼠模型中经口摄入后是否会发生视网膜脉络膜炎和脑囊肿，因为这是与人类相似的感染途径，因此可能在疾病发病机制研究中更具相关性。所有动物在4周内均发病。在16周时通过组织学证实了眼部和脑部炎症，且其炎症程度比原始模型中的要轻。
