Campbell K S
Fox Chase Cancer Center, Institute for Cancer Research, Division of Basic Science, 7701 Burholme Avenue, Philadelphia, PA 19111, USA.
Curr Opin Immunol. 1999 Jun;11(3):256-64. doi: 10.1016/s0952-7915(99)80042-9.
Ligation of the B cell antigen-receptor triggers an intricate maze of intercalated biochemical events that ultimately affect B cell biological responses. Recent advances have helped to connect many loose ends by identifying key adaptor proteins, such as BLNK/SLP-65, defining crucial roles for phosphatidylinositol-3-kinase and mapping pathways controlling the mitogen-activated protein kinases (ERK, JNK and p38).
B细胞抗原受体的连接引发了一系列错综复杂的相互交织的生化事件，这些事件最终影响B细胞的生物学反应。最近的进展通过鉴定关键衔接蛋白（如BLNK/SLP-65）、确定磷脂酰肌醇-3-激酶的关键作用以及绘制控制丝裂原活化蛋白激酶（ERK、JNK和p38）的信号通路，帮助理清了许多头绪。
