Freeman J H, Nicholson D A
Department of Psychology, The University of Iowa, Seashore Hall, Iowa City, IA 52242, USA.
Brain Res. 1999 Jul 3;833(2):225-33. doi: 10.1016/s0006-8993(99)01547-4.
Single-unit neuronal activity was recorded from the cerebellar interpositus nucleus and lateral pontine nuclei during conditioned inhibition of the eyeblink response in rats. Conditioned inhibition training sessions included 100 trials/day for 12 days. During each training session, the rats were given 50 presentations of a tone conditioned stimulus (CS) that was paired with a brief periocular shock unconditioned stimulus (US). They were also given 50 presentations of a compound stimulus that included the tone-CS and a light-CS. The compound-CS was not paired with the US. The two types of trials were mixed throughout the session and presented in an irregular sequence. This training procedure resulted in significant inhibition of the eyeblink response during the compound-CS. Neurons in the interpositus and lateral pontine nuclei exhibited significantly less activity during the compound-CS relative to the tone-CS. The suppression of cerebellar and pontine learning-related neuronal activity during the inhibitory CS may be critical for inhibiting the conditioned eyeblink response.
在大鼠眨眼反应的条件性抑制过程中，记录了小脑间位核和脑桥外侧核的单单位神经元活动。条件性抑制训练 sessions 包括每天100次试验，共12天。在每次训练 session 期间，给大鼠呈现50次音调条件刺激（CS），该刺激与短暂的眼周电击非条件刺激（US）配对。还给它们呈现50次复合刺激，其中包括音调-CS和光-CS。复合-CS未与US配对。这两种类型的试验在整个 session 中混合，并以不规则顺序呈现。这种训练程序导致在复合-CS期间眨眼反应受到显著抑制。与音调-CS相比，间位核和脑桥外侧核中的神经元在复合-CS期间的活动明显减少。在抑制性CS期间小脑和脑桥与学习相关的神经元活动的抑制可能对抑制条件性眨眼反应至关重要。
