5-氟尿嘧啶在犬体内的药代动力学及其向胰液中的渗透情况。
Pharmacokinetics of 5-fluorouracil and its penetration into pancreatic juice in dogs.
作者信息
Zhu Z, Fu Q, Nightingale C H, Zhao Y P, Liao Q, Wang H N, Xue C Q, Yang Z Y, Li D K
机构信息
Department of Pharmacy, Peking Union Medical College Hospital, PUMC, Chinese Academy of Medical Sciences, Beijing, China.
出版信息
Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):7-9.
AIM
To study the pharmacokinetic behavior of 5-fluorouracil (5-FU) in pancreatic juice in dogs and its correlation with 5-FU in plasma, and to evaluate its penetration characteristics.
METHODS
After placing a pancreatico-drainage tube, 8 dogs were injected 5-FU 250 mg i.v. Blood and pancreatic samples were collected and the 5-FU concentrations were determined by HPLC. The pharmacokinetic parameters were obtained with statistical analysis.
RESULTS
The mean slopes of the terminal phase (K10) in plasma and pancreatic juice were 9.4 h-1 and 10.2 h-1, respectively (P > 0.05). The pharmacokinetic behaviors of 5-FU in plasma and pancreatic juice fitted a nonlinear model. Its penetration index was 3.39 +/- 2.84. The penetration of 5-FU from blood to pancreatic juice was relatively rapid, demonstrating a consistently higher concentration in pancreatic juice than in plasma.
CONCLUSIONS
The elimination phase of 5-FU in plasma was similar to that in pancreatic juice, indicating that they were in the same kinetic compartment.
目的
研究5-氟尿嘧啶（5-FU）在犬胰液中的药代动力学行为及其与血浆中5-FU的相关性，并评估其渗透特性。
方法
放置胰液引流管后，8只犬静脉注射250mg 5-FU。采集血液和胰液样本，采用高效液相色谱法测定5-FU浓度。通过统计分析获得药代动力学参数。
结果
血浆和胰液中终末相平均斜率（K10）分别为9.4 h-1和10.2 h-1（P>0.05）。5-FU在血浆和胰液中的药代动力学行为符合非线性模型。其渗透指数为3.39±2.84。5-FU从血液到胰液的渗透相对较快，表明胰液中的浓度始终高于血浆。
结论
5-FU在血浆中的消除相与胰液中的相似，表明它们处于相同的动力学房室。
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