Huang L X, Cheng Z F
Department of Physiology & Biophysics, Fudan University, Shanghai, China.
Zhongguo Yao Li Xue Bao. 1998 Jan;19(1):20-3.
To study effects of sodium L-glutamate microinjection into lateral habenular nucleus (LHN) of rats on the firing of medullary tail-flick related neurons and tail-flick reflex (TF).
Using synchronous recording of unitary neuronal discharges and TF induced by noxious heat.
Chemical stimulation of LHN induced an excitement of the on-cell spontaneous activity, an inhibition of the off-cell spontaneous activity with an enhancement of their TF related responses. The spontaneous firing rate of on-cells increased from 5.8 +/- 2.2 Hz to 10.9 +/- 3.4 Hz while the spontaneous firing rate of off-cells decreased from 11.8 +/- 2.2 Hz to 6.1 +/- 2.2 Hz. Meanwhile the TFL was shortened from 4.04 +/- 0.17 s to 2.97 +/- 0.13 s.
The chemical stimulation of LHN produced a facilitating action on nociceptive spinal defensive reflex. This effect is brought out by the cooperation of on- and off-cells.
研究向大鼠外侧缰核（LHN）微量注射L-谷氨酸对延髓甩尾相关神经元放电及甩尾反射（TF）的影响。
采用对伤害性热刺激诱发的单位神经元放电和TF进行同步记录。
化学刺激LHN可引起开启细胞自发放电活动兴奋，关闭细胞自发放电活动抑制，并增强其与TF相关的反应。开启细胞的自发放电频率从5.8±2.2Hz增加到10.9±3.4Hz，而关闭细胞的自发放电频率从11.8±2.2Hz降低到6.1±2.2Hz。同时，TF潜伏期从4.04±0.17秒缩短至2.97±0.13秒。
LHN的化学刺激对伤害性脊髓防御反射产生易化作用。这种效应是由开启细胞和关闭细胞共同作用产生的。
