S-亚硝基卡托普利对血管运动张力的抑制作用。

Inhibitory effects of S-nitrosocaptopril on vasomotor tone.

作者信息

Lin M J, Yang X P, Wang J, Jia B J, Jia L

机构信息

Department of Physiology, Fujian Medical University, Fuzhou, China.

出版信息

Zhongguo Yao Li Xue Bao. 1998 Sep;19(5):485-8.

PMID:10375817

Abstract

AIM

To study effects of captopril (Cap) and S-nitrosocaptopril (CapNO) on vascular tension.

METHODS

Tension of rabbit aortic rings and perfusion pressure of rat renal artery (PPr) were examined to evaluate the effects of CapNO.

RESULTS

CapNO (3 nmol.L-1-10 mumol.L-1) produced concentration-dependent vasorelaxation response in the rings of rabbit thoracic aortas. Endothelium denudation did not alter the relaxations to CapNO. In contrast, Cap had no vasorelaxing effect on the rings precontracted with phenylephrine. CapNO (10 nmol.L-1) decreased rat PPr in vivo (P < 0.01), and the effect was concentration-dependent and reversible. Cap showed a reduction in rat PPr only at the concentration 1000 nmol.L-1 (P < 0.05). The relaxing potency of CapNO was 100 times higher than that of Cap in this respect. Pre-perfusion of rat renal arteries with NG-monomethyl-L-arginine monoacetate (L-NMMA, 0.03 nmol.L-1) or L-arginine (3 nmol.L-1) did not significantly blocked the relaxing effect induced by CapNO.

CONCLUSION

CapNO had a direct vasodilatory effect.

摘要

目的

研究卡托普利（Cap）和S-亚硝基卡托普利（CapNO）对血管张力的影响。

方法

检测兔主动脉环张力和大鼠肾动脉灌注压（PPr），以评估CapNO的作用。

结果

CapNO（3 nmol·L-1至10 μmol·L-1）在兔胸主动脉环中产生浓度依赖性血管舒张反应。内皮剥脱不改变对CapNO的舒张反应。相反，Cap对用去氧肾上腺素预收缩的环没有血管舒张作用。CapNO（10 nmol·L-1）在体内降低大鼠PPr（P < 0.01），且该作用呈浓度依赖性且可逆。Cap仅在浓度为1000 nmol·L-1时显示大鼠PPr降低（P < 0.05）。在这方面，CapNO的舒张效力比Cap高100倍。用NG-单甲基-L-精氨酸单乙酸盐（L-NMMA，0.03 nmol·L-1）或L-精氨酸（3 nmol·L-1）预灌注大鼠肾动脉并未显著阻断CapNO诱导的舒张作用。