VanSteenhouse J L, Dimski D S, Taylor H W, Swenson D H, Taboada J, Hosgood G
Department of Veterinary Pathology, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803, USA.
Am J Vet Res. 1999 Jun;60(6):749-52.
To evaluate orotic acid (OA) as a possible etiologic factor in cats with idiopathic hepatic lipidosis (HL).
20 clinically normal adult female cats.
Cats were fed a control diet or a diet containing less protein. On day 1 of the control period, blood, urine, and liver biopsy specimens were obtained. Each cat was given an oral dose of water daily. On days 8, 15, and 22, blood and urine specimens were collected as on day 1. On day 29, liver, blood, and urine samples were obtained as on day 1. After a resting period of 30 to 60 days, cats were treated with orotic acid. Serum biochemical analyses, urinary OA-to-creatinine ratios, and liver biopsy specimens were evaluated. Cats were given OA orally (suspension or capsules) for 29 days. Sample collection and data obtained were identical to those described for the control period.
Urinary OA-to-creatinine ratios were significantly higher in all treated cats, but ratios were significantly higher in those receiving OA in capsules than in those receiving OA in suspension. Diet or treatment did not alter hepatic biochemical or histologic variables significantly. However, 7 cats given the highest dose of OA in capsules developed azotemia, urolithiasis, and renal changes.
Most concentrations of OA used in this study did not induce HL in cats during a 29-day period, but the highest dosage used did result in renal disease.
Orotic acid does not appear to be involved in the genesis of HL in cats.
评估乳清酸（OA）作为特发性肝脂肪变性（HL）猫可能的病因。
20只临床正常的成年雌性猫。
给猫喂食对照饮食或蛋白质含量较低的饮食。在对照期第1天，采集血液、尿液和肝脏活检标本。每只猫每天口服一剂水。在第8、15和22天，像第1天一样采集血液和尿液标本。在第29天，像第1天一样采集肝脏、血液和尿液样本。经过30至60天的休息期后，用乳清酸治疗猫。评估血清生化分析、尿OA与肌酐比值以及肝脏活检标本。给猫口服OA（悬浮液或胶囊）29天。样本采集和获得的数据与对照期描述的相同。
所有接受治疗的猫尿OA与肌酐比值均显著升高，但接受胶囊装OA的猫的比值显著高于接受悬浮液装OA的猫。饮食或治疗未显著改变肝脏生化或组织学变量。然而，7只接受最高剂量胶囊装OA的猫出现了氮质血症、尿路结石和肾脏变化。
本研究中使用的大多数OA浓度在29天期间未在猫中诱发HL，但使用的最高剂量确实导致了肾脏疾病。
乳清酸似乎不参与猫HL的发生。
