转铁蛋白受体中一个保守的RGD（精氨酸-甘氨酸-天冬氨酸）基序是与转铁蛋白结合所必需的。
A conserved RGD (Arg-Gly-Asp) motif in the transferrin receptor is required for binding to transferrin.
作者信息
Dubljevic V, Sali A, Goding J W
机构信息
Department of Pathology and Immunology, Monash Medical School, Alfred Hospital, Prahran, Victoria 3181, Australia.
出版信息
Biochem J. 1999 Jul 1;341 ( Pt 1)(Pt 1):11-4.
Abstract
The transferrin receptor contains a highly conserved Arg-Gly-Asp (RGD) sequence in the C-terminal region where transferrin is thought to bind. RGD sequences are commonly involved in cell adhesion. This sequence is crucial for transferrin binding, suggesting possible evolutionary links between molecules mediating iron uptake and cell adhesion.
摘要
转铁蛋白受体在其C末端区域含有一个高度保守的精氨酸-甘氨酸-天冬氨酸（RGD）序列，据认为转铁蛋白就是在此处结合。RGD序列通常参与细胞黏附。该序列对于转铁蛋白结合至关重要，这表明介导铁摄取的分子与细胞黏附分子之间可能存在进化联系。
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