Reitsma J B, Dalstra J A, Bonsel G J, van der Meulen J H, Koster R W, Gunning-Schepers L J, Tijssen J G
Department of Clinical Epidemiology and Biostatistics, Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands.
Heart. 1999 Jul;82(1):52-6. doi: 10.1136/hrt.82.1.52.
To examine the relation between trends over time in mortality and hospital morbidity caused by various cardiovascular diseases in the Netherlands.
Trend analysis by Poisson regression of national data on mortality and hospital admissions from 1975 to 1995.
The Dutch population.
All cardiovascular diseases combined were responsible for 39% of all deaths and 16% of all hospital admissions in 1995. From 1975 to 1995, age adjusted cardiovascular mortality declined by an annual change of -2.0% (95% confidence intervals (CI) -2.1% to -1.9%), while in the same period age adjusted discharge rates increased annually by 1. 3% (95% CI 1.1% to 1.5%). Around 60% of the gain in life expectancy in this period was related to lower cardiovascular mortality. For mortality, major reductions were seen in coronary heart disease (annual change -2.9%) and in stroke (-2.1%), whereas the increase in hospital admissions was mainly caused by chronic manifestations of coronary heart disease (5.1%), heart failure (2.1%), and diseases of the arteries (1.8%). In recent years, the gap between men and women at risk of dying from coronary heart disease became smaller for those aged </= 65 years.
Our findings of a decrease in cardiovascular mortality and an increase in admission rates for chronic conditions such as heart failure, chronic coronary syndromes, and diseases of the arteries, support the hypothesis that the longer survival of many patients with heart diseases is leading to a growing pool of patients at increased risk for subsequent cardiovascular complications in Western countries.
研究荷兰各类心血管疾病所致死亡率和医院发病率随时间的变化关系。
采用泊松回归对1975年至1995年全国死亡率和住院数据进行趋势分析。
荷兰人群。
1995年,所有心血管疾病合计占总死亡人数的39%,占总住院人数的16%。1975年至1995年,年龄调整后的心血管疾病死亡率以每年-2.0%的幅度下降(95%置信区间为-2.1%至-1.9%),而同期年龄调整后的出院率每年上升1.3%(95%置信区间为1.1%至1.5%)。这一时期预期寿命增加的约60%与心血管疾病死亡率降低有关。在死亡率方面,冠心病(年变化-2.9%)和中风(-2.1%)有大幅下降,而住院人数增加主要是由冠心病的慢性表现(5.1%)、心力衰竭(2.1%)和动脉疾病(1.8%)所致。近年来,65岁及以下有死于冠心病风险的男性和女性之间的差距缩小。
我们发现心血管疾病死亡率下降,而心力衰竭、慢性冠状动脉综合征和动脉疾病等慢性病的住院率上升,这支持了以下假设:在西方国家,许多心脏病患者存活时间延长,导致随后发生心血管并发症风险增加的患者群体不断扩大。