Weinberg E D
Department of Biology, Indiana University, Bloomington 47405, USA.
J Eukaryot Microbiol. 1999 May-Jun;46(3):231-8. doi: 10.1111/j.1550-7408.1999.tb05119.x.
To survive and replicate in vertebrate hosts, protozoan and fungal invaders must be capable of securing host iron. Successful pathogens obtain the metal from either extraction of heme, binding of siderophilins, binding of siderophores, and/or iron pools within host cells. The actual strategy can vary with the availability of iron in the particular host milieu. As a corollary, hosts have developed an elaborate iron withholding defense system. Conditions that can compromise the system as well as procedures that can strengthen it are reviewed.
为了在脊椎动物宿主中生存和繁殖，原生动物和真菌入侵者必须能够获取宿主的铁。成功的病原体通过提取血红素、结合亲铁蛋白、结合铁载体和/或宿主细胞内的铁池来获取这种金属。实际策略会因特定宿主环境中铁的可用性而有所不同。相应地，宿主已经发展出一套复杂的铁扣留防御系统。本文综述了可能损害该系统的条件以及可以强化该系统的方法。
