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[不同乙醇与水偏好的大鼠对酒精的代谢适应性]

[Metabolic adaptation to alcohol in rats with different preference of ethanol over water].

作者信息

Bardina L R, Satanovskaia V I

机构信息

Institute of Biochemistry, Grodno, Belarus.

出版信息

Vopr Med Khim. 1999 Mar-Apr;45(2):117-22.

PMID:10378299
Abstract

Recent studies have shown that the phenomenon of ethanol preference by animals and of alcohol consumption by humans may be related to the intensity of its metabolism in the body and depend on the activities of the ethanol and aldehyde metabolizing systems which are potential regulators of the acetaldehyde level in the cell. The special features of adaptative reactions of this system (alcohol dehydrogenase, microsomal ethanol oxidizing system, catalase, aldehyde dehydrogenase) were examined in rats, differing by the preference to water or ethanol (5%, 10%, 15%) under condition of a long contact with alcohol.

摘要

最近的研究表明,动物对乙醇的偏好现象以及人类的酒精消费现象可能与其在体内的代谢强度有关,并取决于乙醇和乙醛代谢系统的活性,这些系统是细胞中乙醛水平的潜在调节因子。在长期接触酒精的条件下,研究了该系统(酒精脱氢酶、微粒体乙醇氧化系统、过氧化氢酶、乙醛脱氢酶)适应性反应的特点,实验对象为对水或乙醇(5%、10%、15%)有不同偏好的大鼠。

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