Loza E, Tinturé T, Sánchez-Ibarrola A
Department of Rheumatology, Hospital of Navarra, Pamplona, Spain.
Rheumatology (Oxford). 1999 Apr;38(4):325-8. doi: 10.1093/rheumatology/38.4.325.
We have studied in peripheral blood (PB) and synovial fluid (SF) of 31 patients diagnosed with rheumatoid arthritis (RA), the expression of CD5 and CD23 antigens on B cells, and the levels of soluble CD23 (sCD23), interleukin-4 (IL-4) and tumour necrosis factor alpha (TNF-alpha). We have also correlated the results with the disease activity index.
CD5+ B cells are expanded in SF and, moreover, show higher expression of CD23 than CD5 - B cells. Twelve patients had detectable levels of IL-4 in plasma and 10 in SF (nine patients in both samples); the absence of IL-4 was related to a higher expression of CD23 on CD5 + B cells and with higher levels of sCD23. A negative correlation was found in SF between TNF-alpha and sCD23 levels.
There is no correlation between disease activity index and the different parameters studied (expression of CD5 and CD23 on B cells, sCD23, IL-4 and TNF-alpha levels) either in plasma/PB or in SF.
我们研究了31例类风湿关节炎（RA）患者外周血（PB）和滑液（SF）中B细胞上CD5和CD23抗原的表达，以及可溶性CD23（sCD23）、白细胞介素-4（IL-4）和肿瘤坏死因子α（TNF-α）的水平。我们还将结果与疾病活动指数进行了关联分析。
CD5+B细胞在滑液中增多，而且与CD5-B细胞相比，其CD23表达更高。12例患者血浆中可检测到IL-4水平，10例患者滑液中可检测到IL-4水平（9例患者在两个样本中均可检测到）；未检测到IL-4与CD5+B细胞上CD23的高表达以及sCD23的高水平有关。在滑液中发现TNF-α与sCD23水平呈负相关。
无论是在血浆/外周血中还是在滑液中，疾病活动指数与所研究的不同参数（B细胞上CD5和CD23的表达、sCD23、IL-4和TNF-α水平）之间均无相关性。
