一些“第二代”和“第四代”抗抑郁药的代谢：茚满二酮、维洛沙嗪、安非他酮、米安色林、马普替林、曲唑酮、奈法唑酮和文拉法辛。
Metabolism of some "second"- and "fourth"-generation antidepressants: iprindole, viloxazine, bupropion, mianserin, maprotiline, trazodone, nefazodone, and venlafaxine.
作者信息
Rotzinger S, Bourin M, Akimoto Y, Coutts R T, Baker G B
机构信息
Department of Psychiatry, University of Alberta, Edmonton, Canada.
出版信息
Cell Mol Neurobiol. 1999 Aug;19(4):427-42. doi: 10.1023/a:1006953923305.
Abstract
- This review summarizes the major known aspects of the metabolism of second-generation (iprindole, viloxazine, bupropion, mianserin, maprotiline, and trazodone) and fourth-generation (nefazodone and venlafaxine) antidepressants. 2. Discussions about specific enzymes involved and about possible pharmacokinetic drug-drug interactions, particularly as they relate to cytochrome P450 enzymes, are provided.
摘要
- 本综述总结了第二代（茚达品、维洛沙嗪、安非他酮、米安色林、马普替林和曲唑酮）和第四代（奈法唑酮和文拉法辛）抗抑郁药代谢的主要已知方面。2. 文中讨论了所涉及的特定酶以及可能的药代动力学药物-药物相互作用，尤其是与细胞色素P450酶相关的相互作用。
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