Dołoto Anna, Bąk Ewelina, Batóg Gabriela, Piątkowska-Chmiel Iwona, Herbet Mariola
Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8B Street, 20-090, Lublin, Poland.
Pharmacol Rep. 2024 Aug;76(4):714-739. doi: 10.1007/s43440-024-00611-7. Epub 2024 Jul 16.
Depression is the fourth most serious disease in the world. Left untreated, it is a cause of suicide attempts, emergence or exacerbation worsening of serious diseases, bodily and mental disorders, as well as increased risk of cardiovascular diseases, stroke, diabetes, and obesity, as well as endocrine and neurological diseases. Frequent coexistence of depression and other diseases requires the simultaneous use of several drugs from different therapeutic groups, which very often interact and intensify comorbidities, sometimes unrelated mechanisms. Sufficient awareness of potential drug interactions is critical in clinical practice, as it allows both to avoid disruption of proper pharmacotherapy and achieve substantive results. Therefore, this review aims to analyze the interactions of antidepressants with other concomitant medications. Against the backdrop of experimental research and a thorough analysis of the up-to-date literature, the authors discuss in detail the mechanisms and effects of action of individual drug interactions and adaptogens, including the latest antidepressants.
抑郁症是世界上第四大严重疾病。若不治疗，它会导致自杀企图、严重疾病的出现或恶化加剧、身心障碍，以及心血管疾病、中风、糖尿病和肥胖症风险增加，还有内分泌和神经疾病。抑郁症与其他疾病常同时存在，这就需要同时使用来自不同治疗组的几种药物，而这些药物常常相互作用并加剧合并症，有时涉及不相关的机制。在临床实践中，充分了解潜在的药物相互作用至关重要，因为这既能避免干扰适当的药物治疗，又能取得实质性效果。因此，本综述旨在分析抗抑郁药与其他同时使用的药物之间的相互作用。在实验研究和对最新文献进行全面分析的背景下，作者详细讨论了个体药物相互作用和适应原（包括最新的抗抑郁药）的作用机制和效果。
