Ursem N T, Clark E B, Keller B B, Wladimiroff J W
Department of Obstetrics and Gynecology, Academic Hospital Rotterdam-Dijkzigt, Erasmus University, The Netherlands.
Ultrasound Obstet Gynecol. 1999 May;13(5):312-6. doi: 10.1046/j.1469-0705.1999.13050312.x.
To examine the variability in fetal heart rate and absolute flow velocity, which are possible hemodynamic markers of cardiovascular homeostasis in pregnancies complicated by diabetes mellitus.
Doppler studies of umbilical artery velocity waveforms were performed at 12-21 weeks of gestation in 16 women with well-controlled type I (insulin-dependent) diabetes mellitus. From umbilical artery velocity waveforms of at least 13 s in duration, we determined absolute values and beat-to-beat variability for fetal heart rate and umbilical artery flow velocities and compared these findings with normal controls matched for gestational age.
Fetuses of diabetic women displayed increased fetal heart rate variability and umbilical artery peak systolic velocity. Fetal heart rate, umbilical artery time-averaged velocity and variability in umbilical artery flow velocity were not essentially different between the two groups.
Fetal heart rate variability and umbilical artery peak systolic velocity may be markers for fetal cardiovascular homeostasis in pregnancies complicated by insulin-dependent diabetes mellitus.
研究胎儿心率和绝对流速的变异性，这两者可能是妊娠合并糖尿病时心血管稳态的血流动力学标志物。
对16例血糖控制良好的Ⅰ型（胰岛素依赖型）糖尿病孕妇在妊娠12至21周时进行脐动脉速度波形的多普勒研究。从持续时间至少13秒的脐动脉速度波形中，我们确定了胎儿心率和脐动脉流速的绝对值及逐搏变异性，并将这些结果与孕周匹配的正常对照组进行比较。
糖尿病孕妇的胎儿心率变异性和脐动脉收缩期峰值流速增加。两组之间胎儿心率、脐动脉时间平均流速和脐动脉流速变异性无本质差异。
胎儿心率变异性和脐动脉收缩期峰值流速可能是妊娠合并胰岛素依赖型糖尿病时胎儿心血管稳态的标志物。
