CD4 低表达 CD8 高表达双阳性 T 淋巴细胞具有颗粒酶 B 阳性 CD8 阳性记忆 T 淋巴细胞的表型。
CD4dullCD8bright double-positive T-lymphocytes have a phenotype of granzyme Bpos CD8pos memory T-lymphocytes.
作者信息
Rentenaar R J, Wever P C, van Diepen F N, Schellekens P T, Wertheim P M, ten Berge I J
机构信息
Department of Internal Medicine, Academic Medical Centre, University of Amsterdam, The Netherlands.
出版信息
Nephrol Dial Transplant. 1999 Jun;14(6):1430-4. doi: 10.1093/ndt/14.6.1430.
BACKGROUND
T-lymphocytes that co-express CD4 and CD8 antigens may be found in small percentages in the peripheral blood of healthy individuals, and have a CD4brightCD8dull phenotype. CD4dullCD8bright T-lymphocytes have been found only in temporal association with some viral infections.
METHODS
Four-colour flow cytometric analysis of peripheral blood mononuclear cells from a renal transplant recipient with cytomegalovirus infection was performed.
RESULTS
A small but clearly distinguishable subpopulation of CD4dullCD8bright double-positive T-lymphocytes was detected, that exhibited phenotypic characteristics of cytotoxic T-lymphocytes and were granzyme B positive. Furthermore, no naive cells appeared to be present within this subpopulation.
CONCLUSIONS
CD4dullCD8bright double-positive T-lymphocytes are enriched for memory and effector cytotoxic T cells.
背景
在健康个体的外周血中，可发现共表达CD4和CD8抗原的T淋巴细胞，比例较小，且具有CD4明亮CD8暗淡的表型。仅在与某些病毒感染的时间关联中发现了CD4暗淡CD8明亮的T淋巴细胞。
方法
对一名肾移植受者合并巨细胞病毒感染的外周血单个核细胞进行四色流式细胞术分析。
结果
检测到一小群但明显可区分的CD4暗淡CD8明亮双阳性T淋巴细胞亚群，其表现出细胞毒性T淋巴细胞的表型特征且颗粒酶B呈阳性。此外，该亚群中似乎不存在初始细胞。
结论
CD4暗淡CD8明亮双阳性T淋巴细胞富含记忆性和效应性细胞毒性T细胞。
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