第二次器官移植后的儿童免疫性大疱性疾病。

Childhood immunobullous disease following a second organ transplant.

作者信息

Morelli J G, Weston W L

机构信息

Department of Dermatology, University of Colorado School of Medicine, Denver, Colorado 80262, USA.

出版信息

Pediatr Dermatol. 1999 May-Jun;16(3):205-7. doi: 10.1046/j.1525-1470.1999.00033.x.

DOI:10.1046/j.1525-1470.1999.00033.x

PMID:10383776

Abstract

Immunobullous diseases are quite unusual in children. We report two children who developed immunobullous disease shortly after a second solid organ transplantation. One child had IgA pemphigus vegetans, the other bullous pemphigoid. We hypothesize that the repeat organ transplantation served as a "booster" immunization for autoantibody production. Both children developed their immunobullous condition while being treated with immunosuppressive drugs that are used to treat immunobullous disorders.

摘要

免疫性大疱性疾病在儿童中相当罕见。我们报告了两名儿童，他们在第二次实体器官移植后不久患上了免疫性大疱性疾病。一名儿童患有增殖型IgA天疱疮，另一名患有大疱性类天疱疮。我们推测重复器官移植充当了自身抗体产生的“加强”免疫。两名儿童在接受用于治疗免疫性大疱性疾病的免疫抑制药物治疗时出现了免疫性大疱性病症。