HIV-1反式激活因子与细胞周期蛋白T1相互作用，引导P-TEFb CTD激酶复合物作用于反式激活应答元件RNA。 - Suppr

Suppr

超能文献

HIV-1 Tat interacts with cyclin T1 to direct the P-TEFb CTD kinase complex to TAR RNA.

作者信息

Garber M E, Wei P, Jones K A

机构信息

Regulatory Biology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037-1099, USA.

出版信息

Cold Spring Harb Symp Quant Biol. 1998;63:371-80. doi: 10.1101/sqb.1998.63.371.

DOI:10.1101/sqb.1998.63.371

PMID:10384302

Abstract

摘要

相似文献

HIV-1 Tat interacts with cyclin T1 to direct the P-TEFb CTD kinase complex to TAR RNA.HIV-1反式激活因子与细胞周期蛋白T1相互作用，引导P-TEFb CTD激酶复合物作用于反式激活应答元件RNA。

Cold Spring Harb Symp Quant Biol. 1998;63:371-80. doi: 10.1101/sqb.1998.63.371.

Human and rodent transcription elongation factor P-TEFb: interactions with human immunodeficiency virus type 1 tat and carboxy-terminal domain substrate.人类和啮齿动物转录延伸因子P-TEFb：与1型人类免疫缺陷病毒tat及羧基末端结构域底物的相互作用

J Virol. 1999 Jul;73(7):5448-58. doi: 10.1128/JVI.73.7.5448-5458.1999.

CDK9 autophosphorylation regulates high-affinity binding of the human immunodeficiency virus type 1 tat-P-TEFb complex to TAR RNA.细胞周期蛋白依赖性激酶9（CDK9）的自磷酸化调节人类免疫缺陷病毒1型反式激活因子-P-TEFb复合物与反式激活应答元件（TAR）RNA的高亲和力结合。

Mol Cell Biol. 2000 Sep;20(18):6958-69. doi: 10.1128/MCB.20.18.6958-6969.2000.

Recruitment of cyclin T1/P-TEFb to an HIV type 1 long terminal repeat promoter proximal RNA target is both necessary and sufficient for full activation of transcription.细胞周期蛋白T1/正性转录延伸因子b（P-TEFb）被招募至HIV-1长末端重复序列启动子近端RNA靶点，这对于转录的完全激活而言，既是必要的，也是充分的。

Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7791-6. doi: 10.1073/pnas.96.14.7791.

Transcription elongation factor P-TEFb mediates Tat activation of HIV-1 transcription at multiple stages.转录延伸因子P-TEFb在多个阶段介导Tat对HIV-1转录的激活作用。

EMBO J. 1998 Jul 1;17(13):3681-91. doi: 10.1093/emboj/17.13.3681.

An in vitro transcription system that recapitulates equine infectious anemia virus tat-mediated inhibition of human immunodeficiency virus type 1 Tat activity demonstrates a role for positive transcription elongation factor b and associated proteins in the mechanism of Tat activation.一种体外转录系统可重现马传染性贫血病毒tat介导的对1型人类免疫缺陷病毒Tat活性的抑制作用，该系统证明了正转录延伸因子b及相关蛋白在Tat激活机制中的作用。

Virology. 2000 Sep 1;274(2):356-66. doi: 10.1006/viro.2000.0480.

The ability of positive transcription elongation factor B to transactivate human immunodeficiency virus transcription depends on a functional kinase domain, cyclin T1, and Tat.正转录延伸因子B反式激活人类免疫缺陷病毒转录的能力取决于一个功能性激酶结构域、细胞周期蛋白T1和反式激活转录蛋白。

J Virol. 1998 Sep;72(9):7154-9. doi: 10.1128/JVI.72.9.7154-7159.1998.

A novel CDK9-associated C-type cyclin interacts directly with HIV-1 Tat and mediates its high-affinity, loop-specific binding to TAR RNA.一种新型的与CDK9相关的C型细胞周期蛋白直接与HIV-1反式激活因子（Tat）相互作用，并介导其与TAR RNA的高亲和力、环特异性结合。

Cell. 1998 Feb 20;92(4):451-62. doi: 10.1016/s0092-8674(00)80939-3.

Optimized chimeras between kinase-inactive mutant Cdk9 and truncated cyclin T1 proteins efficiently inhibit Tat transactivation and human immunodeficiency virus gene expression.激酶失活突变体Cdk9与截短的细胞周期蛋白T1蛋白之间的优化嵌合体可有效抑制Tat反式激活和人类免疫缺陷病毒基因表达。

J Virol. 2002 Nov;76(21):10873-81. doi: 10.1128/jvi.76.21.10873-10881.2002.

Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression.细胞周期蛋白依赖性激酶9（Cdk9）和细胞周期蛋白T1（cyclin T1）在HIV反式激活途径基因表达中的调控功能。

J Cell Biochem. 1999 Dec 1;75(3):357-68.

引用本文的文献

PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex.PRMT2 通过防止核仁出口和 Tat 进入超级延伸复合物的相分离来促进 HIV-1 潜伏期。

Nat Commun. 2023 Nov 10;14(1):7274. doi: 10.1038/s41467-023-43060-1.

A conditional RNA Pol II mono-promoter drives HIV-inducible, CRISPR-mediated cyclin T1 suppression and HIV inhibition.一种条件性RNA聚合酶II单启动子驱动HIV诱导的、CRISPR介导的细胞周期蛋白T1抑制及HIV抑制。

Mol Ther Nucleic Acids. 2023 Apr 19;32:553-565. doi: 10.1016/j.omtn.2023.04.011. eCollection 2023 Jun 13.

From Entry to Egress: Strategic Exploitation of the Cellular Processes by HIV-1.从进入到逸出：HIV-1对细胞过程的策略性利用

Front Microbiol. 2020 Dec 4;11:559792. doi: 10.3389/fmicb.2020.559792. eCollection 2020.

Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection.组织记忆 CD4+T 细胞表达白细胞介素 7 受体-α（CD127），优先支持潜伏的 HIV-1 感染。

PLoS Pathog. 2020 Apr 30;16(4):e1008450. doi: 10.1371/journal.ppat.1008450. eCollection 2020 Apr.

Molecular entrapment by RNA: an emerging tool for disrupting protein-RNA interactions .RNA 分子捕获：一种破坏蛋白质-RNA 相互作用的新兴工具

RNA Biol. 2020 Apr;17(4):417-424. doi: 10.1080/15476286.2020.1717059. Epub 2020 Jan 28.

Advances toward Curing HIV-1 Infection in Tissue Reservoirs.HIV-1 感染组织储库的治愈进展。

J Virol. 2020 Jan 17;94(3). doi: 10.1128/JVI.00375-19.

Structural mechanism for HIV-1 TAR loop recognition by Tat and the super elongation complex.HIV-1 TAR 环识别 Tat 和超级延伸复合物的结构机制。

Proc Natl Acad Sci U S A. 2018 Dec 18;115(51):12973-12978. doi: 10.1073/pnas.1806438115. Epub 2018 Dec 4.

Post-translational Modification-Based Regulation of HIV Replication.基于翻译后修饰的HIV复制调控

Front Microbiol. 2018 Sep 11;9:2131. doi: 10.3389/fmicb.2018.02131. eCollection 2018.

PURA, the gene encoding Pur-alpha, member of an ancient nucleic acid-binding protein family with mammalian neurological functions.PURA基因编码Pur-alpha，它是一个具有哺乳动物神经功能的古老核酸结合蛋白家族的成员。

Gene. 2018 Feb 15;643:133-143. doi: 10.1016/j.gene.2017.12.004. Epub 2017 Dec 6.

Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation.Curaxin CBL0100通过抑制病毒转录延伸来阻断HIV-1复制和激活。

Front Microbiol. 2017 Oct 17;8:2007. doi: 10.3389/fmicb.2017.02007. eCollection 2017.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验