Norton J V, Zager E, Grady J F
University Medical Center, Oak Lawn, IL 60453-2416, USA.
J Foot Ankle Surg. 1999 May-Jun;38(3):238-41. doi: 10.1016/s1067-2516(99)80060-x.
Erythromelalgia is not a commonly recognized or diagnosed condition that affects the lower extremities. The first reported case was in 1878, when Mitchell suggested the term "erythromelalgia." This condition is characterized by a burning sensation with erythema of the involved extremity. When the extremity is lowered, or heat is applied, the pain is intensified. The application of cold or elevation of the extremity will have the opposite effect of decreasing the pain. Erythromelalgia is classified as primary or idiopathic if there is no accompanying disease process. Secondary erythromelalgia is associated commonly with myeloproliferative syndrome-related thrombocythemia, and is mostly evident in adult onset of the condition. Treatment for adults with erythromelalgia includes a single daily dose of aspirin, but children who have no associated underlying disorder find little to no relief with acetylsalicylic acid.
红斑性肢痛症并非一种常见的、已被认知或确诊的影响下肢的病症。首例报告病例出现于1878年，当时米切尔提出了“红斑性肢痛症”这一术语。这种病症的特征是受累肢体出现伴有红斑的灼痛。当肢体下垂或受热时，疼痛会加剧。冷敷或抬高肢体则会产生相反的效果，即减轻疼痛。如果没有伴随的疾病过程，红斑性肢痛症被归类为原发性或特发性。继发性红斑性肢痛症通常与骨髓增殖综合征相关的血小板增多症有关，且在成人发病时最为明显。成年红斑性肢痛症患者的治疗方法包括每日单剂量服用阿司匹林，但对于没有相关潜在病症的儿童来说，乙酰水杨酸几乎无法缓解症状。
