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[针对细小病毒和丹毒的联合疫苗以及相应单价疫苗在不同接种程序下的比较研究。1:田间试验]

[Comparative investigations of a combined vaccine against parvovirus and erysipelas and corresponding monovaccines in different vaccination schedules. 1: Field trial].

作者信息

Ritzmann M, Gerbermann H, Gyra H, Eichinger H M, Heinritzi K

机构信息

II. Medizinischen Tierklinik, Ludwig-Maximilians-Universität München.

出版信息

Tierarztl Prax Ausg G Grosstiere Nutztiere. 1999 May;27(3):168-74.

Abstract

In a field trial, the development of antibodies of a combined vaccine against the porcine parvovirus (PPV) as well as against swine erysipelas was compared with corresponding mono vaccines. Furthermore, these vaccines were used in different vaccination schedules. The tests were carried out on 109 gilts in three closed farms. In all gilts, a basic immunization repeated twice was carried out at the age of six months and at intervals of three weeks. The revaccination was carried out four months after the basic immunization with half of the animals, and six months after the basic immunization with the remaining gilts. Between the combined vaccine and the mono vaccine no significant differences in the development of antibodies against PPV could be found according to different vaccination schedules. The gilts having been vaccinated with the mono vaccine and boostered six months later showed significantly higher antibody titers against Erysipelothrix rhusiopathiae. Between the remaining vaccination groups no significant difference in the development of the antibodies against swine erysipelas could be found. On only one farm, a continuous decrease of antibody titers against PPV in case of altogether 238 non-vaccinated piglets until the sixth month of life could be observed. On the two other farms, an increase of antibody titers against PPV could be found at different points of time, which indicates an infection of the piglets. Between the individual vaccination groups no significant antibody titers against PPV could be measured in milk tests. With regard to the number of piglets born alive per litter, the number of piglets born dead per litter and the number of mummies, a significant difference could neither be found between the vaccination groups 1-4.

摘要

在一项田间试验中,将一种针对猪细小病毒(PPV)以及猪丹毒的联合疫苗的抗体产生情况与相应的单价疫苗进行了比较。此外,这些疫苗采用了不同的接种程序。试验在三个封闭猪场的109头后备母猪上进行。对所有后备母猪,在6月龄时每隔三周进行两次基础免疫。一半的动物在基础免疫后四个月进行再次免疫,其余后备母猪在基础免疫后六个月进行再次免疫。根据不同的接种程序,联合疫苗和单价疫苗在针对PPV的抗体产生方面未发现显著差异。接种单价疫苗并在六个月后进行加强免疫的后备母猪对猪丹毒杆菌显示出显著更高的抗体滴度。在其余接种组之间,针对猪丹毒的抗体产生未发现显著差异。仅在一个猪场,观察到总共238头未接种疫苗的仔猪在6月龄前针对PPV的抗体滴度持续下降。在另外两个猪场,在不同时间点发现针对PPV的抗体滴度有所上升,这表明仔猪受到了感染。在个体接种组之间,乳汁检测中未检测到针对PPV的显著抗体滴度。在每窝活产仔猪数、每窝死产仔猪数和木乃伊胎数方面,接种组1 - 4之间也未发现显著差异。

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