Haddy T B, Rana S R, Castro O
Department of Pediatrics and Child Health and the Sickle Cell Center, Howard University College of Medicine, Washington, District of Columbia, USA.
J Lab Clin Med. 1999 Jan;133(1):15-22. doi: 10.1053/lc.1999.v133.a94931.
Approximately 25% to 50% of persons of African descent and some ethnic groups in the Middle East have benign ethnic neutropenia, with low leukocyte and neutrophil counts. It is important to recognize the existence of this condition, the most common form of neutropenia throughout the world, and thus avoid both under-and overevaluation. Although there is no scientific basis for an absolute neutrophil count of 1.5x10(9)/L to be considered minimal, counts below this level are empirically regarded as inadequate in persons of all ethnic groups who are above the age of 1 year. Many individuals, however, maintain consistently low absolute neutrophil counts without evidence of increased susceptibility to infection or any other adverse effect. The important determination is not how many neutrophils are present in the peripheral blood, but whether the bone marrow is able to produce enough normally functioning cells when needed. A description of benign ethnic neutropenia, as set forth in this review, suggests that the lower limit now considered acceptable for the absolute neutrophil count should be readjusted downward for all ethnic groups.
大约25%至50%的非洲裔人士以及中东的一些族群患有良性种族性中性粒细胞减少症，白细胞和中性粒细胞计数较低。认识到这种病症的存在很重要，它是全球最常见的中性粒细胞减少症形式，因此要避免评估不足和过度评估。虽然将绝对中性粒细胞计数1.5×10⁹/L视为最低值并无科学依据，但对于所有1岁以上的各族群人士，低于这个水平的计数根据经验被认为是不足的。然而，许多人绝对中性粒细胞计数持续偏低，但没有感染易感性增加或任何其他不良反应的证据。重要的判断不是外周血中有多少中性粒细胞，而是骨髓在需要时是否能够产生足够数量功能正常的细胞。正如本综述中所阐述的，对良性种族性中性粒细胞减少症的描述表明，现在认为可接受的绝对中性粒细胞计数下限应对所有族群向下调整。
