生长抑素受体在神经内分泌肿瘤诊断与治疗中的应用

Somatostatin Receptors in the Diagnosis and Therapy of Neuroendocrine Tumor.

作者信息

Wängberg B, Nilsson O, Johanson V, Kölby L, Forssell-Aronsson E, Andersson P, Fjälling M, Tisell L, Ahlman H

机构信息

Departments of Surgery, Pathology, Radiation Physics, and Nuclear Medicine, Sahlgren University Hospital, S-423 45 Goteborg, Sweden.

出版信息

Oncologist. 1997;2(1):50-58.

PMID:10388029

Abstract

The expression of somatostatin receptors in neuroendocrine tumors has facilitated the diagnosis and surgical treatment of patients with these tumors. After injection of a radiolabeled long-acting somatostatin analog, (111)In-octreotide, scintigraphic tumor imaging can ben performed as well as intraoperative tumor localization. During localization studies very high (111)In concentration values were found in tumor tissues versus normal tissues, especially in carcinoid tumors and endocrine pancreatic tumors. Studies on such tumors in cell culture further indicated internalization of (111)In into tumor cells, which is a prerequisite for a radiobiological effect from short range Auger and conversion electrons. Attempts to systemic radionuclide therapy via somatostatin receptors in patients with neuroendocrine tumors have been initiated.

摘要

生长抑素受体在神经内分泌肿瘤中的表达有助于这些肿瘤患者的诊断和外科治疗。注射放射性标记的长效生长抑素类似物（111）铟-奥曲肽后，可进行闪烁肿瘤成像以及术中肿瘤定位。在定位研究中，发现肿瘤组织中的（111）铟浓度值相对于正常组织非常高，尤其是在类癌肿瘤和内分泌胰腺肿瘤中。对这些肿瘤进行的细胞培养研究进一步表明，（111）铟可内化进入肿瘤细胞，这是短程俄歇电子和转换电子产生放射生物学效应的前提条件。针对神经内分泌肿瘤患者，已开始尝试通过生长抑素受体进行全身放射性核素治疗。