Britto C, Geethanjali S, Rameshkumar K
Department of Pathology, St. John's National Academy of Health Sciences, St. Marthas Hospital, Bangalore, Karnataka.
Indian J Cancer. 1998 Dec;35(4):156-63.
Immune response plays an important role in the interaction between malignant neoplasms and their host, which is reflected as histologic changes in the lymph nodes draining tumours.
641 regional lymph nodes from 64 primary carcinomas of breast, stomach and colon were examined to assess such a response.
The lymphnodes were classified into one of the following histological patterns--lymphocyte predominance (LP), germinal centre predominance (GCP), lymphocyte depletion (LD) and unstimulated (U).
LP (T Cell response) was the frequently observed pattern in the lymph nodes of breast and stomach. A similar pattern was observed among the survivors irrespective of the involvement of lymph node with tumour. There was a significant association between the histologic pattern of lymph node and stage & grade of the disease in breast carcinoma.
The correlation of lymph node histology with grade and extent of the disease & survival indicate that the immune system is important in regulating the growth of malignant neoplasms. Such information may help as prognostic indicator and as therapeutic guide for immunotherapy.
免疫反应在恶性肿瘤与其宿主之间的相互作用中起着重要作用，这表现为引流肿瘤的淋巴结的组织学变化。
对来自64例乳腺、胃和结肠癌原发性癌的641个区域淋巴结进行检查，以评估这种反应。
将淋巴结分为以下组织学模式之一——淋巴细胞为主型（LP）、生发中心为主型（GCP）、淋巴细胞耗竭型（LD）和未受刺激型（U）。
LP（T细胞反应）是在乳腺和胃的淋巴结中最常观察到的模式。无论淋巴结是否受肿瘤累及，在幸存者中都观察到类似模式。在乳腺癌中，淋巴结的组织学模式与疾病的分期和分级之间存在显著关联。
淋巴结组织学与疾病的分级、范围及生存的相关性表明，免疫系统在调节恶性肿瘤的生长中很重要。这些信息可能有助于作为预后指标和免疫治疗的治疗指南。
