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创伤性横纹肌溶解症中休克与局部损伤的处理

The management of shock and local injury in traumatic rhabdomyolysis.

作者信息

Nespoli A, Corso V, Mattarel D, Valerio M, Nespoli L

机构信息

Università degli Studi, Milano.

出版信息

Minerva Anestesiol. 1999 May;65(5):256-62.

Abstract

Rhabdomyolysis (literally "striped muscle dissolution") is a biological and clinical condition that takes to plasmatic release of myoglobin, muscle enzymes and electrolytes, relates to the lysis of stripped muscle fibers. Rhabdomyolysis presents the clinician with two distinct problems: local injury and the systemic effects directly related to that injury. Locally, muscle, vessel and nerve compression are the primary issues. Systemic concerns relate to depleted intravascular volume, electrolyte imbalances and renal injury from myoglobin. Preventing the systemic and renal complications of the crush syndrome requires very early and vigorous treatment to sustain the circulation, preferably started at the site of the catastrophe. During the extrication of an injured person from a collapsed building, wrecked automobile, or other site, isotonic saline solution should be infused at the rate of 1.5 liters per hour as soon one of the trapped person's limbs has been freed. Some authors suggest to do a preventive fasciotomy in any suspicious case of compartmental syndrome, when the patient has severe muscular pain of the muscular cavity, tense swelling, hypoesthesia or anesthesia of the muscular cavity, pain at the passive mobilization of the limb. On the other hand other surgeons suggest doing a fasciotomy only in selected group of patients. Therefore, the traumatic rhabdomyolysis has few diagnostically problems. On the other hand, their treatment is complex and must have a multidisciplinary approach. So the rhabdomyolysis actually remain a severe disease with high mortality caused principally by visceral lesions related to sepsis.

摘要

横纹肌溶解症(字面意思为“条纹状肌肉溶解”)是一种生物学和临床病症,会导致肌红蛋白、肌肉酶和电解质释放入血浆,与横纹肌纤维的溶解有关。横纹肌溶解症给临床医生带来两个不同的问题:局部损伤以及与该损伤直接相关的全身影响。局部而言,肌肉、血管和神经受压是主要问题。全身方面的问题涉及血管内血容量减少、电解质失衡以及肌红蛋白导致的肾损伤。预防挤压综合征的全身和肾脏并发症需要非常早期且积极的治疗来维持循环,最好在灾难发生现场就开始。在将受伤人员从倒塌的建筑物、失事的汽车或其他场所救出时,一旦被困人员的一个肢体被解救出来,就应以每小时1.5升的速度输注等渗盐溶液。一些作者建议,在任何疑似筋膜间隔综合征的病例中,当患者出现肌肉腔严重疼痛、紧张性肿胀、肌肉腔感觉减退或麻木、肢体被动活动时疼痛,应进行预防性筋膜切开术。另一方面,其他外科医生则建议仅对选定的患者群体进行筋膜切开术。因此,创伤性横纹肌溶解症诊断方面问题较少。另一方面,其治疗复杂,必须采用多学科方法。所以横纹肌溶解症实际上仍然是一种严重疾病,死亡率高,主要由与脓毒症相关的内脏病变引起。

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