Konishi K, Ueyama T
Department of Clinical Pathology, National Kanazawa Hospital.
Nihon Rinsho. 1999 Jun;57(6):1279-84.
Post-transfusion hepatitis developed in 6 of 447(1.3%) patients who received transfusion even after 1992 when HCV screening by PHA method was started. The six patients were suggested as hepatitis, non-B, non-C, non-G type. Of the six patients, 4 were found to be infected with TTV, which was identified in one of the patients. The patients became positive for TTV DNA before or almost the same time as the development of hepatitis and their amounts of TTV DNA were varied depending on the ALT level, suggesting that their hepatitis might be caused by TTV. The patients who presented hepatitis became positive for TTV DNA in the 6-10th week after transfusion, whereas more than half of the patients with a slight hepatic disorder became positive in the 2-4th week after transfusion. In addition, prolonged infection with TTV was only observed in nearly half of 23 patients.
在447例接受输血的患者中，有6例（1.3%）发生了输血后肝炎，即使在1992年采用PHA方法开始筛查丙型肝炎病毒之后。这6例患者被诊断为非甲、非乙、非丙、非庚型肝炎。在这6例患者中，有4例被发现感染了TTV，其中1例患者的TTV得到了鉴定。这些患者在肝炎发生之前或几乎同时TTV DNA呈阳性，且TTV DNA的量因丙氨酸转氨酶水平而异，提示他们的肝炎可能由TTV引起。出现肝炎的患者在输血后6 - 10周TTV DNA呈阳性，而轻度肝脏疾病患者中超过一半在输血后2 - 4周呈阳性。此外，在23例患者中，近一半仅观察到TTV的长期感染。
