[日本血友病患者中的TT病毒（TTV）]

[TT virus (TTV) in Japanese haemophiliacs].

作者信息

Yokozaki S, Fukuda Y, Hayakawa T, Takamatsu J

机构信息

Second Department of Internal Medicine, Nagoya University School of Medicine.

出版信息

Nihon Rinsho. 1999 Jun;57(6):1427-32.

PMID:10391014

Abstract

This study aimed to evaluate the prevalence and characteristics of infection with a novel virus designated TT virus (TTV) in Japanese haemophiliacs. TTV DNA was measured in 60 haemophiliacs by semi-nested PCR. HCV RNA, HGV RNA and HIV antibody were also tested. TTV DNA was detected in 35 haemophiliacs (58.3%). There were no differences in the backgrounds or characteristics between TTV DNA-positive and-negative haemophiliacs, except that levels of IgG and IgM in TTV DNA-positive patients were higher than those in TTV DNA-negative patients. In patients infected with TTV type 2, which is rare in Japan, the rate of coinfection with HCV of imported types was high. These indicate that TTV type 2 in Japanese haemophiliacs might have a foreign origin.

摘要

本研究旨在评估一种名为TT病毒（TTV）的新型病毒在日本血友病患者中的感染率及感染特征。通过半巢式聚合酶链反应（PCR）对60例血友病患者检测TTV DNA。同时也检测了丙型肝炎病毒（HCV）RNA、庚型肝炎病毒（HGV）RNA及人类免疫缺陷病毒（HIV）抗体。在35例血友病患者（58.3%）中检测到TTV DNA。TTV DNA阳性和阴性血友病患者在背景或特征方面无差异，只是TTV DNA阳性患者的IgG和IgM水平高于TTV DNA阴性患者。在感染2型TTV（在日本较为罕见）的患者中，输入型HCV合并感染率较高。这些表明日本血友病患者中的2型TTV可能来源于国外。