急性髓系白血病M2伴t(8;21)(q22;q22)，具有不寻常表型：髓过氧化物酶(+)、CD13(-)、CD14(-)和CD33(-)。

Acute myeloid leukemia M2 and t(8;21)(q22;q22) with an unusual phenotype: myeloperoxidase (+), CD13 (-), CD14 (-), and CD33(-).

作者信息

García Vela J A, Martin M, Delgado I, García Alonso L, Monteserin M C, Benito L, Somolinos N, Oña F

机构信息

Department of Hematology, Hospital Universitario de Getafe, Madrid, Spain.

出版信息

Ann Hematol. 1999 May;78(5):237-40. doi: 10.1007/s002770050508.

DOI:10.1007/s002770050508

PMID:10391105

Abstract

Cases of myeloid surface antigen-negative acute myeloid leukemia (AML) are rare. We describe the morphological, cytochemical, immunologic, and cytogenetic features of two patients with AML with maturation (FAB M2) and the phenotype MPO+, CD13 (-), CD33(-), CD56(+). Cytogenetic studies demonstrated t(8;21)(q22;q22). These findings suggest an association between the lack of CD13 and CD33 in myeloperoxidase-positive AML and the presence of t(8;21).

摘要

髓系表面抗原阴性的急性髓系白血病（AML）病例罕见。我们描述了两例具有成熟特征的AML（FAB M2型）患者的形态学、细胞化学、免疫学和细胞遗传学特征，其表型为MPO+、CD13(-)、CD33(-)、CD56(+)。细胞遗传学研究显示存在t(8;21)(q22;q22)。这些发现提示髓过氧化物酶阳性的AML中CD13和CD33缺失与t(8;21)的存在之间存在关联。