Schmidt S, Ritz E
Department of Internal Medicine, University of Heidelberg.
Ann Med Interne (Paris). 1999 Feb;150(2):86-90.
Immunoglobulin A glomerulonephritis (IgA-GN) or Berger's disease is the most common glomerulonephritis when diagnosis is based on renal biopsy. The disease has a variable clinical course. Abnormalities in the production and/or catabolism of IgA are thought to play an important role in the etiology and pathogenesis of IgA-GN. Some evidence suggests that genetic factors determine the susceptibility to develop IgA-GN. Furthermore it has been proposed that genetic factors determine also the rate of progression. Since hypertension is an important predictor of progression, genes involved in blood pressure regulation have been analysed. A polymorphism in the gene for the angiotensin converting enzyme has been reported to be associated with progression. Further studies and progress in molecular biology will help to further elucidate the genetic factors which contribute to the development and progression of IgA-GN.
免疫球蛋白A肾小球肾炎（IgA-GN）或伯杰氏病是基于肾活检诊断时最常见的肾小球肾炎。该病临床病程多变。IgA产生和/或分解代谢异常被认为在IgA-GN的病因和发病机制中起重要作用。一些证据表明遗传因素决定了发生IgA-GN的易感性。此外，有人提出遗传因素也决定疾病进展速度。由于高血压是疾病进展的重要预测指标，因此对参与血压调节的基因进行了分析。据报道，血管紧张素转换酶基因的一种多态性与疾病进展有关。分子生物学的进一步研究和进展将有助于进一步阐明促成IgA-GN发生和发展的遗传因素。
