Sanz Pérez G, Arocena García-Tapia J, Zudaire Bergera J J, Díez-Caballero F, Martín-Marquina A, Rodríguez-Rubio Cortadellas F, Rosell-Costa D, Robles J E, Berián Polo J M
Departamento de Urología, Clínica Universitaria de Navarra, Pamplona.
Actas Urol Esp. 1999 Apr;23(4):323-6.
Chromophobe renal cell carcinoma, described in 1985 is a type of renal carcinoma which is relatively uncommon (5%). Although the majority of studies published suggest a more favourable prognosis, conclusive evidence does not exist. In this study we present the clinical and ultrastructural characteristics and particularly the prognoses of 15 patients taken from a group of 230, all of whom had been diagnosed as suffering from renal carcinoma and for which they had received surgical treatment.
230 kidneys were analysed between June 1990 and December 1997. The tissue was fixed and dyed with H-E, Hale's acid iron colloid and PAS. Two models were defined, typical and eosinophil. In 8 cases the tissue was processed in order to quantify the DNA using flow cytometry.
Of the 230 kidneys analyzed, 15 were identified as being compatible with a diagnosis of chromophobe carcinoma, representing 6.5% of the group studied whilst 73% corresponded to the typical model. The average follow-up period for the 15 patients studied was of three and a half years. Upon completion of the study, 14 out of the 15 patients were still alive and the remaining one had died from causes unrelated to his illness. The average period of survival was 43 months. The tumors had an average diameter of 7.9 cm. The nuclear grade was GII on 10 occasions (seven T2, one T3a and two T3b) and GIII on 5 (four T2, one T3a and two T3b). The study of flow cytometry showed four cases of multiploids two of aneuploids one tetraploid and one diploid.
Chromophobe renal cell carcinoma is a relatively uncommon (6.5%) type of renal carcinoma. The typical ultrastructural type is the most common (73%). The highly favourable pathologic stage (p2 73%) and the significantly low nuclear grade (66% GII) suggest that this is a tumour with a rather better prognosis, as is shown by an increased period of survival.
1985年被描述的嫌色性肾细胞癌是一种相对少见的肾癌类型（占5%）。尽管大多数已发表的研究表明其预后较好，但尚无确凿证据。在本研究中，我们呈现了从230例患者中选取的15例患者的临床和超微结构特征，尤其是预后情况，这230例患者均被诊断为患有肾癌并接受了手术治疗。
在1990年6月至1997年12月期间对230个肾脏进行了分析。组织用苏木精 - 伊红（H - E）、黑尔酸性铁胶体和过碘酸雪夫（PAS）染色固定。定义了两种类型，典型型和嗜酸性型。8例组织进行了处理以便用流式细胞术对DNA进行定量分析。
在分析的230个肾脏中，15个被确定符合嫌色性癌的诊断，占所研究组的6.5%，而73%符合典型类型。所研究的15例患者的平均随访期为三年半。研究结束时，15例患者中有14例仍然存活，其余1例死于与疾病无关的原因。平均生存期为43个月。肿瘤平均直径为7.9厘米。核分级为GII级的有10例（7例T2期，1例T3a期和2例T3b期），GIII级的有5例（4例T2期，1例T3a期和2例T3b期）。流式细胞术研究显示四倍体4例、非整倍体2例、四倍体1例和二倍体1例。
嫌色性肾细胞癌是一种相对少见的肾癌类型（占6.5%）。典型的超微结构类型最为常见（占73%）。高度有利的病理分期（p2占73%）和显著较低的核分级（66%为GII级）表明这是一种预后较好的肿瘤，生存期延长就表明了这一点。
